Single neuron labeling with Cre-mediated inducible knockout (SLICK) in mice

Above: schematics for SLICK-mediated conditional transgene expression or gene knockout

Below: genetic manipulation, illustrated by LacZ expression in a Cre reporter line, occurs only in a small subpopulation of neurons, which simultaneously express YFP for imaging purposes. See Diesseroth et al., (2006), J. Neurosci. 26:10380-6