Duke Neurobiology
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Laboratory of Anne West, Ph.D.MainLab PersonnelRecent Papers
Deng, J.V., Rodriguez, R.M., Hutchinson, A.N., Kim, I.-H., Wetsel, W.C., and West, A.E. (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nature Neurosci, in press..
Pfenning, A.R., Kim, T.-K., Spotts, J.M., Hemberg, M., Su, D., and West, A.E. (2010) Genome-wide identification of Calcium-Response Factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. PLoS One, 5: e10870..
McDowell, K.A., Hutchinson, A.N., Wong-Goodrich, S.J.E., Presby, M.M., Su, D., Rodriguiz, R.M., Law, K.C., Wiliams, C.L., Wetsel, W.C., and West, A.E. (2010) Reduced cortical BDNF expression and aberrant memory in Carf knockout mice. J Neurosci, 30: 7453-7465.
Hutchinson, A.N. and West, A.E. (2010) Transcriptional regulators that mediate neural and behavioral adaptations to psychostimulants. Cell Science 6: 140-177.
Kokobu, M., Nishio, M., Ribar, T.J., Anderson, K.A., West, A.E., and Means, A.R. (2009) BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. J. Neurosci. 29: 8901-8913.
West, A.E. (2008) Activity-Dependent Regulation of Brain-derived neurotrophic factor Transcription. In Transcriptional Regulation by Neuronal Activity, Ed. By S. Dudek. Springer, NY, NY. pp. 155-174.
Hong, E.J., West, A.E., and Greenberg, M.E. (2005) Transcriptional control of cognitive development. Curr. Op. Neurobiol. 15: 21-28.
West, A.E. and Greenberg, M.E. (2004) Free advice on lab management (book review). Nat. Neurosci. 10: 1017.
Chen, W.G., Chang, Q., Lin, Y., Meissner, A., West, A.E., Griffith, E.C., Jaenisch, R., and Greenberg, M.E. (2003) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science. 302: 885-889.
Chen, W.G., West, A.E., Tao, X., Corfas, G., Szentirmay, M.., Sawadogo, M., Vinson, C., and Greenberg, M.E. (2003) Upstream Stimulatory Factors are mediators of Ca2+-responsive transcription in neurons. J. Neurosci. 23: 2572-2581.
Tao, X.*, West A.E.*, Chen, W.G., Corfas, G., and Greenberg, M.E. (2002) A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron, 33: 383-395. (*equal contribution)
West, A.E., Griffith, E.C., and Greenberg, M.E. (2002) Regulation of transcription factors by neuronal activity. Nature Rev. Neurosci. 3: 921-931.
West, A.E., Chen, W.G., Dalva, M.B., Dolmetsch, R.E., Kornhauser, J.M., Shaywitz, A.J., Takasu, M.A., Tao, X., and Greenberg, M.E. (2001) Calcium regulation of neuronal gene expression. Proc. Natl. Acad. Sci USA, 98: 11024-11031.
Bonni, A., Brunet, A., West, A.E., Datta, S.R., Takasu, M.A., and Greenberg, M.E. (1999). Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science, 286: 1358-1362.
West A.E., Provoda, C., Neve, R.L. and Buckley, K.M.. (1997) Protein targeting in neurons and endocrine cells. in Catecholamines: Bridging Basic Science with Clinical Medicine, Ed. by David Goldstein. Adv. Pharmacol., v.42, p. 247-249.
West, A.E., Neve, R.L. and Buckley, K.M. (1997) Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor . J. Neurosci., 17:6038-6047.
West, A.E., Neve, R.L., and Buckley, K.M.. (1997)Targeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: Evidence for two distinct sorting steps. J. Cell Biol., 139: 917-927.
West, A.E. (1996) Protein Targeting in Neurons [Dissertation]. Cambridge, MA: Harvard University. 243 pp.