Professor of Neurobiology
Faculty Network Member of the Duke Institute for Brain Sciences
Member of the Duke Cancer Institute
Office:
301D Bryan Research
Campus mail:
Box 3209, Durham, NC 27710
Phone:
(919) 681-1909
Email address:
west@neuro.duke.edu
The long term goal of our laboratory is to understand at a cellular/molecular level how neuronal activity regulates the formation and maturation of synapses during brain development, and ultimately to use genetic model systems to understand how defects in this developmental process lead to cognitive dysfunction.
Education and Training
- Cornell University, B.A. 1989
- Harvard University , M.D. 1998
- Harvard University , Ph.D. 1998
Associated Faculty Labs
Selected Grants and Awards
- Cell and Molecular Biology Training Program
- Mechanisms Regulating Vascular Homeostasis
- Genetic and Genomics Training Grant
- Pharmacological Sciences Training Grant
- Noncoding regulation of gene transcription in human neurons
- Neurobiology Training Program
- Functional and Mechanistic Dissection of GPCR Endosomal Signaling Dynamics
- Psychostimulant-Induced Plasticity of Nucleus Accumbens Interneurons
- Modulation of the Perineuronal Net Protein Brevican in the Nucleus Accumbens, and its Impact on Addiction-like Behavior
- Epitranscriptomic Regulation of Synaptic Responses to Drugs of Abuse
- The Role of the Lysine-Specific Histone Demethylase 6b, Kdm6b In Synapse Maturation
- Medical Scientist Training Program
- IRES Track 1 IRTG Engaged in Dissecting and Reengineering the Regulatory Genome
- Chromatin Mechanisms of Neuronal Maturation
- Training Program in Developmental and Stem Cell Biology
- In Vivo Epigenome Editing with CRISPR-Based Histone Acetyltransferase Transgenic Mice
- Bioinformatics and Computational Biology Training Program
- Epigenome Editing Technologies to Control Diverse Biological Functions
- HARDAC-M: Enabling memory-intensive computation for genomics
- Epigenomic modulation of psychostimulant-inducible Fosb in the nucleus accumbens
- Genetics Training Grant
- Organization and Function of Cellular Structure
- Pharmacological Sciences Training Program
- Basic predoctoral training in neuroscience
- Regulation of Cocaine Reward and Reinforcement by MeCP2
- Genome-Wide Mapping of Enhancer Elements for Neuronal Differentiation Genes
- Training in Fundamental &Translational Neuroscience
- Amphetamine-Induced Transcriptional Plasticity in Striatal GABAergic Interneurons
- Regulation of response to chronic antidepressant treatment by MeCP2
- Development of a Platform for Imaging Activity-Dependent Transcription in Neurons
- Behavioral and Synaptic Consequences of MeCP2 Phosphorylation
- Epigenetic regulation of transcriptional repression by drugs of abuse
- A role for the epigenetic factor MeCP2 in neural response to psychostimulants
Department Affiliation
- Department of Neurobiology