Current clinical research interests include clinical trials regarding adaptive deep brain stimulation and gene therapy in Parkinson's disease, Alzheimer's disease, deep brain stimulation for depression, and sensory restoration for development of brain machine interfaces. Clinical treatments include deep brain stimulation, which is now a common procedure for treating Parkinson's disease and tremor. Basic science research interests focus on evaluation of metabolism changes with aging and Alzheimer's disease, particularly in response to ischemia and hypoglycemia, as well as epilepsy and seizure mechanisms as functions of both post-lesion injury and aging brain. These basic science interests include new approaches to optical imaging of the brain, cellular understanding of metabolism using direct substrate recordings (ie, oxygen, glucose, lactate) and developing new methods to understand complex interactions between neurons, astrocytes and blood vessels. Further interests include changes in cerebral blood flow with stroke, neurovascular coupling, and spreading depolarization.
Education and Training
- Indiana University at Bloomington, B.A. 1971
- Indiana University at Bloomington, M.A. 1973
- Indiana University, School of Medicine, M.D. 1975
- University of Minnesota, Medical School, Intern
- University of Washington, Resident, Neurological Surgery
- University of Oslo, Norway , Fellowship, Functional Neurosurgery
Selected Grants and Awards
- A Double-Blind, Randomized, Controlled Trial of Epidural Conus Medullaris Stimulation in patients with Subacute Thoracic Spinal Cord Injury to improve Pain and augment Rehabilitation
- NINDS Research Education Programs for Residents and Fellows in Neurosurgery
- Temporal Patterns of Deep Brain Stimulation
- Scalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous Potentials
- High resolution awake cortical recordings to analyze the role of spreading depolarizations during dynamic stroke evolution
- Hippocampal Neurovascular Plasticity in CVN-AD Mouse: Fornix-Septal Stimulation
- IPA - Francesca Galeffi
- Basic predoctoral training in neuroscience
- Recording Evoked Potentials for Closed-Loop DBS
- Mechanisms of Parkinsonian Impulsivity in Human Subthalamic Nucleus
- Training in Fundamental &Translational Neuroscience
- Neuronal Fatigue in Aging Hippocampus during Sustained Metabolic Demand
- Realistic Human Perception of Spatio-Temporal Thalamic Microstimulation
- Lifespan Metabolic Neuroprotection during Hypoglycemia
- Lifespan Neuronal/Flial Metabolism During Hypoglycemia
- Psychophysical Studies of Cochlear Efferent Function
- Neuronal and post lesion plasticity in aging hippocampus
- Neuronal And Post Lesion Plasticity In Aging Hippocampus
- Neuronal And Post-Lesion Plasticity In Aging Hippocampus
Department Affiliation
- Department of Surgery (Neurosurgery)