Jesse Skene

Associate Research Professor of Neurobiology
Director, Neurogenomics Core Lab
Faculty Network Member of the Duke Institute for Brain Sciences
Associate of the Duke Initiative for Science & Society
Office: 427F Bryan Research
Campus mail: 427F Bryan Res Bldg, Durham, NC 27710
Phone: (919) 681-6346
Email address: skene@neuro.duke.edu

Extension of long axons is essential for the formation of connections in the developing nervous system, and for effective regeneration of pathways interrupted by traumatic injury, stroke, or other insults in the adult CNS.

This laboratory is exploring how changes in genes expression during development alter the ability of neurons to support long axon extension, and the extent to which the re-activation of critical genes limits regeneration in the adult CNS. Global gene expression profiling with DNA microarrays has shown that spinal cord injury often fails to activate expression of a core set of genes associated with axon elongation during both normal development and successful regeneration of peripheral nerves. Functional analysis of axon outgrowth has shown further that expression of these key genes is required for the onset of an "elongating" mode of axon extension needed for effective regeneration in vivo. Ongoing studies are investigating the factors that limit expression of these growth-associated genes in the mature CNS, and potential treatment regimens that may enhance axon regrowth by activating expression of genes required for elongation.

Education and Training

  • Washington University, Ph.D. 1980