Ru-Rong Ji

Professor in Anesthesiology

Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine

Professor in Neurobiology

Professor in Cell Biology

Email address: ru-rong.ji@duke.edu

Chronic pain is a major health problem in the US, affecting 100 million Americans. The long-term goal of the lab is to identify molecular and cellular mechanisms that underlie the genesis of chronic pain and, furthermore, to develop novel pain therapeutics that can target these mechanisms. We are interested in the following questions. (1) How do neuroinflammation and activation of glial cells (microglia and astrocytes) regulate pain and spinal cord synaptic plasticity via neuro-glial and neuro-immune interactions? (2) How do secreted miRNAs regulate neuronal signaling and synaptic transmission and pain as novel neuromodulators and pain mediators? (3) How do pro-resolution lipid mediators such as resolvins and protectin control pain via GPCR and arrestin signaling? (4) Do pain and itch share similar mechanisms? (5) How does Toll-like receptor (TLR) signaling in primary sensory neurons regulate pain and itch? (6) How can bone marrow stem cells produce long-term pain relief via secreting anti-inflammatory and trophic factors? We employ a multidisciplinary approach that covers in vitro, ex vivo, and in vivo electrophysiology, neuronal and glial cell biology, transgenic mice, and behaviors.

Education and Training

Chinese Academy of Sciences (China), Ph.D. 1990

Associated Faculty Labs

Ji Lab

Selected Grants and Awards

Department Affiliation

Department of Anesthesiology

Publications

Wang, Zilong, Changyu Jiang, Hongyu Yao, Ouyang Chen, Sreya Rahman, Yun Gu, Junli Zhao, Yul Huh, and Ru-Rong Ji. “Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition.” Brain, December 27, 2020. https://doi.org/10.1093/brain/awaa430.

Brigham, Natasha C., Rebecca Nofsinger, Xin Luo, Nathan Z. Dreger, Alexandra K. Abel, Tiffany P. Gustafson, Seth P. Forster, Andre Hermans, Ru-Rong Ji, and Matthew L. Becker. “Controlled release of etoricoxib from poly(ester urea) films for post-operative pain management.” J Control Release 329 (December 3, 2020): 316–27. https://doi.org/10.1016/j.jconrel.2020.11.052.

Rimola, Vittoria, Lisa Hahnefeld, Junli Zhao, Changyu Jiang, Carlo Angioni, Yannick Schreiber, Tabea Osthues, et al. “Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain.” J Neurosci 40, no. 49 (December 2, 2020): 9519–32. https://doi.org/10.1523/JNEUROSCI.1223-20.2020.

Jiang, Changyu, Zilong Wang, Christopher R. Donnelly, Kaiyuan Wang, Amanda S. Andriessen, Xueshu Tao, Megumi Matsuda, Junli Zhao, and Ru-Rong Ji. “PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia.” Iscience 23, no. 10 (October 23, 2020): 101570. https://doi.org/10.1016/j.isci.2020.101570.

Donnelly, Christopher R., Ouyang Chen, and Ru-Rong Ji. “How Do Sensory Neurons Sense Danger Signals?” Trends Neurosci 43, no. 10 (October 2020): 822–38. https://doi.org/10.1016/j.tins.2020.07.008.

Chandra, Sharat, Zilong Wang, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong Ji, and Andrey V. Bortsov. “Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch.” Anesthesiology 133, no. 3 (September 1, 2020): 611–27. https://doi.org/10.1097/ALN.0000000000003427.

Chandra, Sharat, Zilong Wang, Xueshu Tao, Ouyang Chen, Xin Luo, Ru-Rong Ji, and Andrey V. Bortsov. “Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch.” Anesthesiology 133, no. 3 (September 2020): 611–27. https://doi.org/10.1097/ALN.0000000000003427.

Wang, Kaiyuan, Yun Gu, Yihan Liao, Sangsu Bang, Christopher R. Donnelly, Ouyang Chen, Xueshu Tao, Anthony J. Mirando, Matthew J. Hilton, and Ru-Rong Ji. “PD-1 blockade inhibits osteoclast formation and murine bone cancer pain.” J Clin Invest 130, no. 7 (July 1, 2020): 3603–20. https://doi.org/10.1172/JCI133334.

Tao, Xueshu, Michael S. Lee, Christopher R. Donnelly, and Ru-Rong Ji. “Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain.” Neurotherapeutics 17, no. 3 (July 2020): 886–99. https://doi.org/10.1007/s13311-020-00892-9.

Donnelly, Christopher R., Amanda S. Andriessen, Gang Chen, Kaiyuan Wang, Changyu Jiang, William Maixner, and Ru-Rong Ji. “Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain.” Neurotherapeutics 17, no. 3 (July 2020): 846–60. https://doi.org/10.1007/s13311-020-00905-7.