From a molecule to an odor. My research is focused on the description of olfaction process at the atomic level. I build a virtual olfactory system by means of computational and microbiology approaches in order to simulate the neuronal mechanism of the perception of smell. This way, I may help elucidating links between the structure of a chemical and its odor. During my PhD at the University of Nice Sophia Antipolis, I have computationally investigated the interaction between odorant compounds and odorant receptors, but my long-term aim is to fully understand the link between odorant receptors and odorants at a molecular level as well as between odorant receptors and odor perception.
Associated labs, publications, & achievements
T. Tong, S. E. Ryu, Y.Min, C.A. de March, C. Bushdid, J. Golebiowski, C. Moon, T. Park
Olfactory receptor 10J5 responding to α-cedrene regulates hepatic steatosis via the cAMP–PKA pathway, Scientific report 7 (1), 2017
A. Gros, V. Manera, C.A. de March, N. Guevara, A. Koenig, L. Friedman, P. Robert, J. Golebiowski, R. David
Olfactory disturbances in aging with and without dementia: towards new diagnostic tools, Journal of Laryngology & Otology p 1-8 , 2017
Y. Yu#, C.A. de March#, K. A. Adipietro, M. J. Ni, J. Golebiowski*, H. Matsunami*, M. Ma* Broad Responsiveness of G Protein-Coupled Odorant Receptors Is Partially Attributed to the Activation Mechanism, PNAS, 112 p 14966-14971, 2015 7.
C.A. de March#, Y. Yu#, K.A. Adipietro, M.J. Ni, H. Matsunami, M. Ma, J. Golebiowski, Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptor. JACS 137 p 8611–8616, 2015
C.A. de March, S.-K. Kim, S. Antonczak, W.A. Goddard III, J. Golebiowski G protein-coupled odorant receptors: From sequence to structure. Protein Science, 24 p 1543-1548, 2015
C.A. de March, S. Ryu, G. Sicard, C. Moon, J. Golebiowski Structure Odour Relationship reviewed in the postgenomic era. Flavor and Fragrance Journal 30 p 342-36, 2015
C.A. de March, J. Golebiowski A Computational microscope focused on the sense of smell. Biochimie, 107 p 1-3, 2014
J. Topin, C.A. de March, L. Charlier, C. Ronin, S. Antonczak, J. Golebiowski Discrimination between Olfactory Receptor agonists and non-agonists, Chemistry a European Journal, 20 (33) p 10227–10230, 2014
C. Delasalle, C.A.de March, U. Meierhenrich, H. Brevard, J. Golebiowski, N. Baldovini Structure-Odor Relationships of hemisynthetic b-santalol analogues, Chemistry & Biodiversity, 11 (11) p 1843-60, 2014
L. Charlier, J. Topin, C.A. de March, P. Lai, C. Crasto, J. Golebiowski, Chap. 4. Molecular Modeling of Olfactory Receptors. in “Olfactory Receptors” Humana Press.Ed. 2013.