Isabella Fallon

The ability to combine a series of actions into an ordered sequence is essential for executing complex behaviors and this process is impaired by Parkinson’s and Huntington’s diseases. The mechanisms underlying sequence production are unknown however, striatal projecting intratelencephalic (IT) and pyramidal tract (PT) pathways from the motor cortex may regulate sequence learning and performance. My research employs in-vivo calcium imaging, closed-loop optogenetics, and machine-learning based behavioral analysis to examine these cell populations during sequence production.