Some ion channels in the cell membrane were found or proposed to be activated by mechanical stimuli (aka. the stretch-activated ion channels). The mechanotransduction, converting mechanical stimuli to cellular responses, is essential in various biological processes including the senses of touch and hearing. My current research projects are focused on the molecular mechanisms of mechanotransduction in neuronal cells. I overexpress or knockdown the stretch-activated ion channels (or candidates) , and characterize the cell responses to the mechanical stimuli.
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