Calakos Publications

Selected Publications

Complete List of Published Work in MyBibliography


Lungu C, Ozelius L, Standaert D, Hallett M, Sieber BA, Swanson-Fisher C, Berman BD, Calakos N, Moore JC, Perlmutter JS, Pirio Richardson SE, Saunders-Pullman R, Scheinfeldt L, Sharma N, Sillitoe R, Simonyan K, Starr PA, Taylor A, Vitek J. Defining research priorities in dystonia.  Neurology. 2020 Mar 24;94(12):526-537. 

O’Hare J, Calakos N, Yin HH. Recent Insights into Corticostriatal Circuit Mechanisms underlying Habits: Invited review for Current Opinions in Behavioral Sciences. Curr Opin Behav Sci. 2018 Apr;20:40-46.

Hernandez-Martinez, R. and N. Calakos. Seq-ing the Circuit Logic of the Basal GangliaTrends Neurosci, Jun, 2017.

O'Hare JK, Li H, Kim N, Gaidis E, Ade K, Beck J, Yin H, Calakos N. Striatal fast-spiking interneurons selectively modulate circuit output and are required for habitual behavior. Elife. 2017 Sep 5;6. pii: e26231. doi: 10.7554/eLife.26231.

Wang X, Gallegos DA, Pogorelov VM, O'Hare JK, Calakos N, Wetsel WC, West AE. Parvalbumin Interneurons of the Mouse Nucleus Accumbens are Required For Amphetamine-Induced Locomotor Sensitization and Conditioned Place Preference. Neuropsychopharmacology. 2017 Aug 25. doi: 10.1038/npp.2017.178. [Epub ahead of print]

Rittiner, J.E.*, Caffall, Z.F.*, Hernandez-Martinez, R., Sanderson, S.M., Pearson, J.L., Tsukayama, K.K., Liu, A.Y., Xiao, C., Tracy, S., Hickey, P., Johnson, J., Scott, B., Stacy, M., Saunders-Pullman, R., Bressman, S., Simonyan, K., Sharma, N.,  Ozelius, L.J.,  Cirulli, E.T., and N. Calakos .  Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for DystoniaNeuron, 2016 Dec 21;92(6):1238-1251.

Ade, K., Wan, Y., Hamman, H., O’Hare, J.K., Guo, W., Quian, A., Kumar, S., Bhagat, S., Rodriguiz, R.M., Wetsel, W.C., Conn, P.J., Dzirasa, K., Huber, K., and N. Calakos. 2016. Excess ongoing mGluR5 signaling drives OCD-like behavior in miceBiological Psychiatry, May 13, PMID: 27436084.

O’Hare, J.K., Ade, K., Sukharnikova, T., Yin, H.H., and N. Calakos. Pathway-specific striatal substrates for making and breaking a habit. Neuron, 2016 (NIHMS 753257, Publ.ID: NEURON12985).

Rossi, M.A., Calakos, N., and H. H. Yin. Spotlight on Movement Disorders:What optogenetics has to offer. Movement Disorders, 2015

Deng, J., Wan, Y., Wang, X., Cohen, S., Wetsel, W.C., Greenberg, M., Kenny, P., N. Calakos, and A. West. 2014. MeCP2 phosphorylation limits psychostimulant-induced behavioral and neuronal plasticity. The Journal of Neuroscience, 34(13)4519-27.

Wan, Y., Ade, K., Caffall, Z., Ozlu, M. I., Eroglu, C., Feng, G., and N. Calakos. 2013. Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. Biological Psychiatry.

Yang, Y. and N. Calakos. Presynaptic Long-Term Synaptic Plasticity. Front Synaptic Neurosci. 5:8. doi: 10.3389/fnsyn.2013.00008 (2013).

Farrell, M.S., Pei, Y., Wan, Y., Yadav, P., Daigle, T.L., Setola, V., Sciaky, N., Simmons, A., Nonneman, R.J., Guettier, J-M., Moy, S., Wess, J., Caron, M.G., Calakos, N., and B.L. Roth. 2012. A Gas DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. Neuropsychopharmacology. 38(5):854-62.

Wan, Y., Feng, G. and N. Calakos. 2011. Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. The Journal of Neuroscience. 31(46):16685-91. PMC3475185.

Yang, Y. and N. Calakos. 2011. Munc13 is required for presynaptic long-term potentiation. The Journal of Neuroscience. 31(33):12053-7. PMC3201725.

Chen, M., Wan, Y., Ade, K., Ting, J., Feng, G., and N. Calakos. 2011. Sapap3 deletion causes anomalous endocannabinoid-mediated synaptic plasticity by enhancing group 1 metabotropic glutamate receptor activity. The Journal of Neuroscience, 31(26):9563-73. PMC3367431.

Ade, K., Wan, Y., Chen, M., Gloss, B. and N. Calakos. 2011. An improved BAC transgenic fluorescent reorter line for sensitive and specific identification of striatonigral medium spiny neurons. Frontiers in Neuroscience 5 (32):1-9, PMC3113108.

Yang, Y. and N. Calakos. 2010. Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1 serine 413 is not required for mossy fiber LTP. The Journal of Neuroscience, 30(7):2542-6, PMC2947440.

Calakos, N., Patel, V.D., Gottron, M., Wang, G., Tran-Viet, K.-N., Brewington, D., Beyer, J.L., Steffens, D.C., Krishnan, R.R., and S. Zuchner. 2009. Functional evidence implicating a novel TOR1A mutation in idiopathic, late-onset focal dystonia. Journal of Medical Genetics, 47(9):646-50, PMC2891583.

Shuen, J.A., Chen, M., Gloss, B., and N. Calakos, 2008. Drd1a-tdTomato transgenic mice for simultaneous visualization of MSNs in the direct and indirect pathways of the basal ganglia. The Journal of Neuroscience, 28(11):2681-5.

Welch, J.M., Lu, J., Rodriguiz, R.M., Trotta, N.C., Peca, J., Ding, J-D., Feliciano, C., Adams, J.P., Dudek, S.M., Weinberg, R.J., Calakos, N., Wetsel, W.C., and Feng, G., 2007. Cortico-striatal synaptic defects and OCD-like behaviors in SAPAP3 mutant mice. Nature, 448(7156): 894-900.

Calakos, N., Schoch, S., Sudhof, T.C., and R.C. Malenka. 2004. Multiple Roles for the Active Zone Protein RIM1a in Late Stages of Neurotransmitter Release. Neuron 42(6):889-896 [Highlighted in Nat. Rev. Neurosci. 5(8):601, 2004]

Calakos, N., M.K. Bennett, K.E. Peterson and R.H. Scheller. 1994. Protein-Protein Interactions Contributing to the Specificity of Intracellular Vesicular Trafficking. Science 263:1146-1149.

Bennett, M.K., N. Calakos and R.H. Scheller. 1992. Syntaxin: A Synaptic Protein Implicated in Docking of Synaptic Vesicles at Presynaptic Active Zones. Science 257:255-259.

Bennett, M.K., N. Calakos, T. Kreiner and R.H. Scheller. 1991. Synaptic Vesicle Membrane Proteins Interact to Form a Multimeric Complex. The Journal of Cell Biology, 116:761-775.


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