Marc Caron, Ph.D., PI
We investigate the molecular bases of brain dysfunctions as they relate to neurological and neuropsychiatric disorders in genetically engineered mouse models. Our studies use biochemical, cellular and behavioral approaches to determine how new concepts of neuromodulation through GPCRs and transporters can be leveraged to develop more selective and effective therapies.
Dopamine, serotonin, and norepinephrine are key neurotransmitters in the central nervous system that regulates behavior and mobility. Studies of the mechanisms of action and regulation of these and other neurotransmitters and hormones at the cellular and molecular levels constitute the main goals of our research activities. Our laboratory uses a wide variety of techniques including animal models, cell systems, and molecular approaches to investigate how G protein-coupled receptors (GPCR) and neurotransmitter transporters regulate homeostasis in health and diseases.