Caron Publications

Slosky, Lauren M., Yushi Bai, Krisztian Toth, Caroline Ray, Lauren K. Rochelle, Alexandra Badea, Rahul Chandrasekhar, et al. “β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.” Cell 181, no. 6 (June 11, 2020): 1364-1379.e14. https://doi.org/10.1016/j.cell.2020.04.053.
Li, Yan-Chun, Priyalakshmi Panikker, Bo Xing, Sha-Sha Yang, Cassandra Alexandropoulos, Erin P. McEachern, Rita Akumuo, et al. “Deletion of Glycogen Synthase Kinase-3β in D2 Receptor-Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor-Dependent Synaptic Plasticity.” Biol Psychiatry 87, no. 8 (April 15, 2020): 745–55. https://doi.org/10.1016/j.biopsych.2019.10.025.
Boone, Peter G., Lauren K. Rochelle, Joshua D. Ginzel, Veronica Lubkov, Wendy L. Roberts, P. J. Nicholls, Cheryl Bock, et al. “A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.” Nat Commun 10, no. 1 (December 2, 2019): 5490. https://doi.org/10.1038/s41467-019-13330-y.
Jacobsen, Jacob P. R., Adrianna Oh, Rachel Bangle, Wendy L. Roberts, Elizabeth L. Royer, Nathan Modesto, Sonora A. Windermere, et al. “Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept.” Neuropsychopharmacology 44, no. 12 (November 2019): 2082–90. https://doi.org/10.1038/s41386-019-0400-1.
Martini, Michael L., Caroline Ray, Xufen Yu, Jing Liu, Vladimir M. Pogorelov, William C. Wetsel, Xi-Ping Huang, John D. McCorvy, Marc G. Caron, and Jian Jin. “Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.” Acs Chem Neurosci 10, no. 9 (September 18, 2019): 4160–82. https://doi.org/10.1021/acschemneuro.9b00410.
Pinkerton, Anthony B., Satyamaheshwar Peddibhotla, Fusayo Yamamoto, Lauren M. Slosky, Yushi Bai, Patrick Maloney, Paul Hershberger, et al. “Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.” J Med Chem 62, no. 17 (September 12, 2019): 8357–63. https://doi.org/10.1021/acs.jmedchem.9b00340.
Porter-Stransky, Kirsten A., Alyssa K. Petko, Saumya L. Karne, L Cameron Liles, Nikhil M. Urs, Marc G. Caron, Carlos A. Paladini, and David Weinshenker. “Loss of β-arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids.” Addict Biol, August 23, 2019, e12823. https://doi.org/10.1111/adb.12823.
Toth, Krisztian, Karim Nagi, Lauren M. Slosky, Lauren Rochelle, Caroline Ray, Suneet Kaur, Sudha K. Shenoy, Marc G. Caron, and Larry S. Barak. “Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs.” Acs Pharmacol Transl Sci 2, no. 4 (August 9, 2019): 230–46. https://doi.org/10.1021/acsptsci.9b00018.
Israelyan, Narek, Andrew Del Colle, Zhishan Li, Yeji Park, Albert Xing, Jacob P. R. Jacobsen, Ruth Ann Luna, et al. “Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.” Gastroenterology 157, no. 2 (August 2019): 507-521.e4. https://doi.org/10.1053/j.gastro.2019.04.022.
Pydi, Sai P., Shanu Jain, Wesley Tung, Yinghong Cui, Lu Zhu, Wataru Sakamoto, Shalini Jain, et al. “Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis.” Nat Commun 10, no. 1 (July 3, 2019): 2936. https://doi.org/10.1038/s41467-019-11003-4.