Franks Lab Publications

Olfactory Circuits

Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states.
Bolding KA, Nagappan S, Han, BX, Wang F & Franks KM. (2020) eLife 2020;9:e53125.
doi: 10.7554/eLife.53125. PMID: 32662420

Structure and flexibility in cortical representations of odour space.
Pashkovski SL, Iurilli G, Brann D, Chicharro D, Drummey K, Franks KM, Panzeri S, Datta SR. (2020)
Nature 583:253-258. doi: 10.1038/s41586-020-2451-1. PMID: 32612230.

Odor coding in piriform cortex: mechanistic insights into distributed coding.
Blazing RM & Franks KM. (2020) Curr. Opin. Neurobiol.  64: 96-102.
doi: 10.1016/j.conb.2020.03.001. PMID: 32422571.

Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis.
Platt MP, Bolding KA, Wayne CR, Chaudry S, Cutforth T, Franks KM & Agalliu D. (2020) PNAS 117: 6708—16.
doi: 10.1073/pnas.1911097117. PMID: 32161123.

Recurrent cortical circuits implement concentration-invariant odor coding.
Bolding KA & Franks KM. (2018) Science 361: eaat6904.
doi: 10.1126/science.aat6904. PMID: 30213885.

A transformation from temporal to ensemble coding in a model of piriform cortex.
Stern M, Bolding KA, Abbott LF & Franks KM. (2018) eLife 10.7554/eLife.34831.
doi: 10.7554/eLife.34831. PMID: 29595470.

Learning: Plasticity without Stabilization in Olfactory Cortex.
Nagappan S & Franks KM. (2018) Curr. Biol. 28: R23-R25.
doi: 10.1016/j.cub.2017.11.010. PMID: 29316416.

Complementary codes for odor identity and odor intensity in olfactory cortex.
Bolding KA & Franks KM. (2017) eLife 10.7554/eLife.22630.

Odor identity coding by distributed ensembles of neurons in the mouse olfactory cortex.
Roland B, Deneux T, Franks KM, Bathellier B, Fleischmann A. (2017) eLife 10.7554/eLife.26337.

A transformation from temporal to ensemble coding in a model of piriform cortex.
Stern M, Bolding KA, Abbott LF & Franks KM. (2017) bioRxiv.

Massive normalization of olfactory bulb output in mice with a “monoclonal nose.”
Roland B, Jordan R, Sosulski DL, Diodato A, Fukunaga I, Wickersham I, Franks KM, Schaefer AT & Fleischmann A.  (2016)  eLife 10:7554/eLife.16335.

I Want It All and I Want It Now: How a Neural Circuit Encodes Odor with Speed and Accuracy.
Franks KM. (2015)  Neuron. 88: 852-4.

Multi-step signaling from sensory neurons onto olfactory bulb mitral cells. 
Gire DH*, Franks KM*, Zak JD, Tanaka KF, Whitesell JD, Mulligan AA, Hen R, Schoppa NE. (2012) J. Neurosci. 32: 2964-75.

Recurrent circuitry dynamically shapes the activation of piriform cortex.
Franks KM, Russo MJ, Sosulski DL, Mulligan AA, Siegelbaum SA, Axel, R. (2011) . Neuron. 72: 49-56.

Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination.
Fleischmann A, Shykind BM, Sosulski DL, Franks KM, Glinka ME, Mei DF, Sun Y, Kirkland J, Mendelsohn M, Albers MW, Axel R. (2008)  Neuron. 60: 1068-81.

Strong single-fiber sensory inputs to olfactory cortex: implications for olfactory coding
Franks KM, Isaacson JS. (2006) Neuron. 49: 357-363.

Synapse specific downregulation of NMDA receptors by early experience: a critical period for plasticity of sensory input to olfactory cortex
Franks KM, Isaacson JS. (2005) Neuron. 47: 101-114.

* denotes equal authorship

Technology Development

Single-cell genetic transfection via in vivo whole-cell recording: bridging physiology, genetics and connectomics.
Rancz EA*, Franks KM*, Schwartz, M Schaefer AT, Seeburg P, Margrie TW. (2011)  Nature Neuroscience. 14: 527-532.

Older Publications

NGF is essential for hippocampal plasticity and learning.
Conner JM*, Franks KM*, Titterness AK*, Russell K, Merrill DA, Christie BR, Sejnowski TJ, Tuszynski MH. (2009)  J. Neurosci. 29: 10883-10889.

Calmodulin activation by calcium transients in the postsynaptic density of dendritic spines
Keller DK, Franks KM, Bartol TM, Sejnowski TJ. (2008) PLoS One. 3: e2045.

Independent sources of synaptic variability at single glutamatergic synapses
Franks KM, Stevens CF, Sejnowski TJ. (2003) J. Neurosci. 23: 3186-3195.

Complexity of calcium signaling in synaptic spines.
Franks KM, Sejnowski TJ. (2002)  Bioessays. 24: 1130-1144.

A Monte Carlo model reveals independent signaling at central glutamatergic synapses
Franks KM*, Bartol TM*, Sejnowski, TJ. (2002) Biophys J. 83: 2333-2348.

An MCell model of calcium dynamics and frequency-dependence of calmodulin activation in dendritic spines
Franks KM, Bartol TM, Sejnowski TJ. (2001). Neurocomputing. 38-40: 9-16.

Synaptic plasticity in morphologically identified CA1 Stratum Radiatum interneurons and projection cells.
Christie BR, Franks KM, Seamans JK, Saga K, Sejnowski, TJ. (2000).  Hippocampus. 10: 678-683.

Russo, Marco J., Kevin M. Franks, Roxanne Oghaz, Richard Axel, and Steven A. Siegelbaum. “Synaptic Organization of Anterior Olfactory Nucleus Inputs to Piriform Cortex.” J Neurosci 40, no. 49 (December 2, 2020): 9414–25. https://doi.org/10.1523/JNEUROSCI.0965-20.2020.
Blazing, Robin M., and Kevin M. Franks. “Neuroscience: Illuminating Principles of Odor Coding.” Curr Biol 30, no. 20 (October 19, 2020): R1279–81. https://doi.org/10.1016/j.cub.2020.08.024.
Blazing, Robin M., and Kevin M. Franks. “Odor coding in piriform cortex: mechanistic insights into distributed coding.” Curr Opin Neurobiol 64 (October 2020): 96–102. https://doi.org/10.1016/j.conb.2020.03.001.
Pashkovski, Stan L., Giuliano Iurilli, David Brann, Daniel Chicharro, Kristen Drummey, Kevin M. Franks, Stefano Panzeri, and Sandeep Robert Datta. “Author Correction: Structure and flexibility in cortical representations of odour space.” Nature 584, no. 7822 (August 2020): E38. https://doi.org/10.1038/s41586-020-2615-z.
Bolding, Kevin A., Shivathmihai Nagappan, Bao-Xia Han, Fan Wang, and Kevin M. Franks. “Recurrent circuitry is required to stabilize piriform cortex odor representations across brain states.” Elife 9 (July 14, 2020). https://doi.org/10.7554/eLife.53125.
Pashkovski, Stan L., Giuliano Iurilli, David Brann, Daniel Chicharro, Kristen Drummey, Kevin M. Franks, Stefano Panzeri, and Sandeep Robert Datta. “Structure and flexibility in cortical representations of odour space.” Nature 583, no. 7815 (July 2020): 253–58. https://doi.org/10.1038/s41586-020-2451-1.
Platt, Maryann P., Kevin A. Bolding, Charlotte R. Wayne, Sarah Chaudhry, Tyler Cutforth, Kevin M. Franks, and Dritan Agalliu. “Th17 lymphocytes drive vascular and neuronal deficits in a mouse model of postinfectious autoimmune encephalitis.” Proc Natl Acad Sci U S A 117, no. 12 (March 24, 2020): 6708–16. https://doi.org/10.1073/pnas.1911097117.
Bolding, Kevin A., and Kevin M. Franks. “Recurrent cortical circuits implement concentration-invariant odor coding.” Science 361, no. 6407 (September 14, 2018). https://doi.org/10.1126/science.aat6904.
Stern, Merav, Kevin A. Bolding, L. F. Abbott, and Kevin M. Franks. “A transformation from temporal to ensemble coding in a model of piriform cortex.” Elife 7 (March 29, 2018). https://doi.org/10.7554/eLife.34831.
Nagappan, Shivathmihai, and Kevin M. Franks. “Learning: Plasticity without Stabilization in Olfactory Cortex.” Curr Biol 28, no. 1 (January 8, 2018): R23–25. https://doi.org/10.1016/j.cub.2017.11.010.