The Liedtke Lab aims to deconstruct sensing mechanisms at the molecular, cellular, organ/systems and organismal level. More specifically, our interest is focused on osmotic and mechanical stimuli as highly relevant sensory cues.
The sensory system most pertinent for our mission is the nociceptive system of the nervous system, which is necessary to evoke pain in conscious animals including humans, yet directs aversive behavior in virtually all animals that have a nervous system.
Because of the relevance for pain and nociception, pathophysiologically relevant modulatory co-stimuli such as inflammatory mediators are being considered.
Finally, neural transmission mechanisms of such stimuli are being explored.