Research Roundup: May 2018

Tuesday, June 5, 2018
By Jennifer Kornbluth
neurons

Here are summaries of a selection of the papers published by Duke Neurobiology in May 2018:

Neural cell biology:

New research from Al La Spada, MD, PhD, and colleagues offers insights into the development of the hallmark motor neuron pathology in human amyotrophic lateral sclerosis (ALS) patients by studying ALS4, a rare, early-onset, inherited form of ALS. Read more

Anne West's lab reviewed how chromatin regulation acts locally to modulate the expression of specific genes and more broadly to coordinate gene expression programs during transitions between cellular states. These data highlight the importance of epigenetic transcriptional mechanisms in postmitotic neurons. Read more

Teleza Westbrook and Greg Field were part of a team showing that more than 99% of retinal ganglion cells (RGCs) express nogo-66 receptor 1 (NgR1), suggesting that inhibition of NgR1 function may ubiquitously promote the regeneration of axons by RGCs, with therapeutic potential reversing optic nerve atrophy. Read more

Senses:

Amanda Lewis and Jörg Grandl discuss ‘Cellular Mechanism for Aged Induced Itch’ in Science. Read more