The neurobiology of late-onset Alzheimers Disease: Clues from the aging rhesus monkey cortex

October 31, 2017 -
12:00pm to 1:00pm
Amy Arnsten; hosted by Fan Wang

Amy Arnsten is a professor of neuroscience and psychology at Yale School of Medicine. The Arnsten Lab studies molecular influences on the higher cognitive circuits of the prefrontal cortex (PFC), with the overarching goal of developing rational treatments for cognitive disorders in aging and mental illness.

The lab uses a multi-disciplinary approach to understand mechanisms influencing working memory at the cellular and behavioral levels. Research has focused on how neuromodulators such as norepinephrine (NE), dopamine (DA) and acetycholine (Ach), dynamically modulate PFC network strength through intracellular signaling mechanisms that open or close potassium channels near glutamate NMDA receptor synapses on dendritic spines.