Evans Lab
The focus of the Evans Lab is to mechanistically define these diverse mitochondrial quality control pathways, including mitochondrial fusion and fission events, mitochondrial derived vesicles, and mitophagy. Our goal is to understand how these pathways collaborate to regulate the mitochondrial network in healthy neurons and what goes wrong in neurodegenerative disease. We integrate advanced live-cell microscopy to visualize mitochondrial dynamics with biochemical techniques and proteomics to define the specificity of these mechanisms in primary neurons, iPSCs, and mouse models of disease.
Featured Publications
Evans CS, Holzbaur ELF. Lysosomal degradation of depolarized mitochondria is rate-limiting in OPTN-dependent neuronal mitophagy. Autophagy. 2020 May;16(5):962-964. doi: 10.1080/15548627.2020.1734330. Epub 2020 Mar 4. PubMed PMID: 32131674.
Evans CS, Holzbaur ELF. Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons. Elife. 2020 Jan 14;9. doi: 10.7554/eLife.50260. PubMed PMID: 31934852.
Evans CS, Holzbaur ELF. Quality Control in Neurons: Mitophagy and Other Selective Autophagy Mechanisms. J Mol Biol. 2020 Jan 3;432(1):240-260. doi: 10.1016/j.jmb.2019.06.031. Epub 2019 Jul 8. Review. PubMed PMID: 31295455.
Hoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z. The ADP/ATP translocase drives mitophagy independent of nucleotide exchange. Nature. 2019 Nov;575(7782):375-379. doi: 10.1038/s41586-019-1667-4. Epub 2019 Oct 16. PubMed PMID: 31618756.
Evans CS, Holzbaur ELF. Autophagy and mitophagy in ALS. Neurobiol Dis. 2019 Feb;122:35-40. doi: 10.1016/j.nbd.2018.07.005. Epub 2018 Jul 5. Review. PubMed PMID: 29981842.