Bradley Goldstein, MD, PhD, PI
Principal Investigator
Associate Professor of Head and Neck Surgery and Communication Sciences
Associate Professor in Neurobiology
Contact Information

Email: bradley.goldstein@duke.edu

External lab site: sites.duke.edu/goldsteinlab

Campus mail: 40 Duke Medicine Circle, DUMC Box 3805, Durham, NC 27710

Phone: (919) 684-3834

Location
MSRB1 Room 485

Goldstein Lab

Education

University of Virginia, B.A. 1992

State University of New York Upstate Medical University, M.D. 1999

State University of New York Upstate Medical University, Ph.D. 1999

Johns Hopkins Medicine, Surgery Intern, Surgery

Johns Hopkins Medicine, Otolaryngology Resident, Surgery

A surgeon-scientist, Dr. Goldstein focuses his clinical work on rhinology and sinus surgery with an interest on olfactory loss. His basic research program is broadly focused on understanding damage and repair in the peripheral olfactory system, using cell culture and mouse models as well as human tissue and single-cell techniques. Current projects seek to identify aging-related changes in human olfactory mucosa; to understand how certain epigenetic complexes regulate adult olfactory neurogenesis; and (more recently) to identify how the novel coronavirus may cause prolonged olfactory dysfunction, in collaborations with Drs. Matsunami, Moseman and Heaton. There is a significant unmet need for effective therapies for anosmia, and the long term goal of these projects is to identify new treatment strategies.

External Lab Site

 

Selected Publications

Oliva AD, Issa K, Hachem RA, Jang D, Gupta R, Moseman EA, Matsunami H, Goldstein BJ. Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans. bioRxiv. 2021: doi: 10.1101/2021.08.09.455538.

Brann DH, … Goldstein BJ, Grubb MS, Ngai J and Datta SR. Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. Sci Adv. 2020 Jul 31;6(31):eabc5801. doi: 10.1126/sciadv.abc5801. Epub 2020 Jul 24. PMID: 32937591.

Mainland JD, Barlow L, Munger S, Millar S, Cheng A, Vergara N, Jiang P, Schwob JE, Goldstein BJ, Holt J, Boye S, Martens J, Leopold D, Bartoshuk L, Doty R, Hummel T, Pinto J, Trimmer C, Kelly K, Pribitkin E and Reed DR. Identifying treatments for taste and smell disorders: gaps and opportunities. Chem Senses. 2020 Jun 18:bjaa038. doi: 10.1093/chemse/bjaa038. Online ahead of print. PMID: 32556127.

Durante MA, Kurtenbach S, Sargi ZB, Harbour JW, Choi R, Kurtenbach S, Goss GM, Matsunami H, Goldstein BJ. Single-cell analysis of olfactory neurogenesis and differentiation in adult humans. Nat Neurosci. 2020 Mar;23(3):323-326. doi: 10.1038/s41593-020-0587-9. PMID: 32066986.

Kurtenbach S, Goss GM, Goncalves S, Choi R, Hare JM, Chaudhari N and Goldstein BJ. Cell-based therapy restores olfactory function in an inducible model of hyposmia. Stem Cell Reports, 2019, May 16. pii: S2213-6711(19)30146-8. doi: 10.1016/j.stemcr.2019.05.001. PMID: 31155504.

Goldstein BJ, Goss GM, Choi R, Saur D, Seidler B, Hare J and Chaudhari N. Contribution of Polycomb group proteins to olfactory basal stem cell renewal in a novel c-Kit+ culture model and in vivo. Development, 143(23):4394-4404, Dec 2016. PMID: 27789621.

Goldstein Publications

Oliva, Allison D., Rupali Gupta, Khalil Issa, Ralph Abi Hachem, David W. Jang, Sebastian A. Wellford, E Ashley Moseman, Hiroaki Matsunami, and Bradley J. Goldstein. “Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans.” J Clin Invest, January 6, 2022. https://doi.org/10.1172/JCI155506.


Ackall, Feras Y., Khalil Issa, Ian Barak, Jordan Teitelbaum, David W. Jang, Sin-H Jung, Bradley Goldstein, Ricardo Carrau, and Ralph Abi Hachem. “Survival Outcomes in Sinonasal Poorly Differentiated Squamous Cell Carcinoma.” Laryngoscope 131, no. 4 (April 2021): E1040–48. https://doi.org/10.1002/lary.29090.


Choi, Rhea, Stefania Goncalves, Michael A. Durante, and Bradley J. Goldstein. “On the in vivo origin of human nasal mesenchymal stem cell cultures.” Laryngoscope Investig Otolaryngol 5, no. 6 (December 2020): 975–82. https://doi.org/10.1002/lio2.472.


Mainland, Joel D., Linda A. Barlow, Steven D. Munger, Sarah E. Millar, M Natalia Vergara, Peihua Jiang, James E. Schwob, et al. “Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities.” Chem Senses 45, no. 7 (October 9, 2020): 493–502. https://doi.org/10.1093/chemse/bjaa038.


Brann, David H., Tatsuya Tsukahara, Caleb Weinreb, Marcela Lipovsek, Koen Van den Berge, Boying Gong, Rebecca Chance, et al. “Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.” Sci Adv 6, no. 31 (July 31, 2020). https://doi.org/10.1126/sciadv.abc5801.


Goncalves, Stefania, and Bradley J. Goldstein. “Acute N-Acetylcysteine Administration Ameliorates Loss of Olfactory Neurons Following Experimental Injury In Vivo.” Anat Rec (Hoboken) 303, no. 3 (March 2020): 626–33. https://doi.org/10.1002/ar.24066.


Durante, Michael A., Stefan Kurtenbach, Zoukaa B. Sargi, J William Harbour, Rhea Choi, Sarah Kurtenbach, Garrett M. Goss, Hiroaki Matsunami, and Bradley J. Goldstein. “Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.” Nat Neurosci 23, no. 3 (March 2020): 323–26. https://doi.org/10.1038/s41593-020-0587-9.


Choi, Rhea, Sarah Kurtenbach, and Bradley J. Goldstein. “Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation.” Int Forum Allergy Rhinol 9, no. 9 (September 2019): 993–99. https://doi.org/10.1002/alr.22366.


Kurtenbach, Sarah, Garrett M. Goss, Stefania Goncalves, Rhea Choi, Joshua M. Hare, Nirupa Chaudhari, and Bradley J. Goldstein. “Cell-Based Therapy Restores Olfactory Function in an Inducible Model of Hyposmia.” Stem Cell Reports 12, no. 6 (June 11, 2019): 1354–65. https://doi.org/10.1016/j.stemcr.2019.05.001.


Goldstein, Bradley J., Rhea Choi, and Garrett M. Goss. “Multiple polycomb epigenetic regulatory proteins are active in normal and regenerating adult olfactory epithelium.” Laryngoscope Investig Otolaryngol 3, no. 5 (October 2018): 337–44. https://doi.org/10.1002/lio2.180.