Associate Professor in Medicine
Assistant Professor of Cell Biology
Assistant Professor in Neurobiology
Faculty Network Member of the Duke Institute for Brain Sciences
307 Research Dr., Nanaline Duke, Rm 213, Durham, NC 27710
Box 3711, DUMC, Durham, NC 27710
Email: huanghe.yang@duke.edu
Location: 213 Nanaline Duke
H. Yang Lab
Our laboratory focuses on the biology of ion and lipid flip-flop across cell membranes in the nervous system and beyond. Utilizing multidisciplinary approaches, we aim to: 1) elucidate the mechanisms of ion and lipid transport through cell membranes; 2) uncover the biological functions of ion and lipid transport in health and disease; and 3) develop innovative strategies to target ion and lipid transport for the treatment of various human diseases. These include neurological disorders such as epilepsy, movement disorders, and neurodegenerative diseases; thrombotic conditions like stroke and heart attack; and pregnancy disorders including preterm birth, growth restriction, and preeclampsia.
H. Yang Research
- How are ions and lipids transported through cell membranes?
- What are the biological functions of ion and lipid transport in health and disease?
- How can we precisely target ion and lipid transport to treat diseases?
For information on Huanghe Yang Lab research:
Publications
Dong, Ping, Yang Zhang, Arsen S. Hunanyan, Mohamad A. Mikati, Jianmin Cui, and Huanghe Yang. “Neuronal mechanism of a BK channelopathy in absence epilepsy and dyskinesia.” Proc Natl Acad Sci U S A 119, no. 12 (March 22, 2022): e2200140119. https://doi.org/10.1073/pnas.2200140119.
Chen, Yong, Zi-Long Wang, Michele Yeo, Qiao-Juan Zhang, Ana E. López-Romero, Hui-Ping Ding, Xin Zhang, et al. “Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.” Gastroenterology 161, no. 1 (July 2021): 301-317.e16. https://doi.org/10.1053/j.gastro.2021.03.049.
Liang, Pengfei, and Huanghe Yang. “Molecular underpinning of intracellular pH regulation on TMEM16F.” J Gen Physiol 153, no. 2 (February 1, 2021). https://doi.org/10.1085/jgp.202012704.
Le, Son C., Pengfei Liang, Augustus J. Lowry, and Huanghe Yang. “Gating and Regulatory Mechanisms of TMEM16 Ion Channels and Scramblases.” Front Physiol 12 (2021): 787773. https://doi.org/10.3389/fphys.2021.787773.
Le, Son C., and Huanghe Yang. “Structure-Function of TMEM16 Ion Channels and Lipid Scramblases.” Adv Exp Med Biol 1349 (2021): 87–109. https://doi.org/10.1007/978-981-16-4254-8_6.
Le, Son C., and Huanghe Yang. “An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation.” Cell Rep 33, no. 13 (December 29, 2020): 108570. https://doi.org/10.1016/j.celrep.2020.108570.
Liao, Chengheng, Yang Zhang, Cheng Fan, Laura E. Herring, Juan Liu, Jason W. Locasale, Mamoru Takada, et al. “Identification of BBOX1 as a Therapeutic Target in Triple-Negative Breast Cancer.” Cancer Discov 10, no. 11 (November 2020): 1706–21. https://doi.org/10.1158/2159-8290.CD-20-0288.
Zhang, Guohui, Rebecca A. Gibson, Marie McDonald, Pengfei Liang, Po Wei Kang, Jingyi Shi, Huanghe Yang, Jianmin Cui, and Mohamad A. Mikati. “A Gain-of-Function Mutation in KCNMA1 Causes Dystonia Spells Controlled With Stimulant Therapy.” Mov Disord 35, no. 10 (October 2020): 1868–73. https://doi.org/10.1002/mds.28138.
Le, Trieu, Son C. Le, Yang Zhang, Pengfei Liang, and Huanghe Yang. “Evidence that polyphenols do not inhibit the phospholipid scramblase TMEM16F.” J Biol Chem 295, no. 35 (August 28, 2020): 12537–44. https://doi.org/10.1074/jbc.AC120.014872.
Zhang, Yang, Trieu Le, Ryan Grabau, Zahra Mohseni, Hoejeong Kim, David R. Natale, Liping Feng, Hua Pan, and Huanghe Yang. “TMEM16F phospholipid scramblase mediates trophoblast fusion and placental development.” Sci Adv 6, no. 19 (May 2020): eaba0310. https://doi.org/10.1126/sciadv.aba0310.
Lab Members
Alumni
Yang Zhang, PhD. Assistant Professor, Shenzhen Bay Laboratory, China
Takefumi Kawai, PhD. Assistant Professor, Osaka University, Japan
Trieu Le, PhD. Postdoctoral associate, The Hospital for Sick Children, Canada
Son Le, PhD. Research Scientist, Gilead Sciences Inc.
Ping Dong, PhD. Research Associate, UNC Chapel Hill
Contact/Join H. Yang Lab
Department of Biochemistry
Duke University School of Medicine
Telephone:
Lab: 919-681-0175
Office: 919-684-1406
Fax: 919-613-5145
Mailing Address:
Box 3711, DUMC
Durham, NC 27710
Physical Address:
307 Research Drive
Nanaline Duke, Room 213
Durham, NC 27710
Positions
We’re always looking for talented, motivated scientists of any level to join us.
Postdoctoral fellows
Please e-mail Huanghe at huanghe.yang@duke.edu with your CV, a short description about your background, your major contributions and interest in our lab.
Graduate students
This lab is affiliated with several Duke graduate programs and may accept rotation at any time of year. Please contact Huanghe at huanghe.yang@duke.edu to discuss a potential rotation.
Undergraduates
Please send an e-mail with a short note about your interest in our lab, your CV, and a transcript to Huanghe at huanghe.yang@duke.edu.
Staff
Candidates please e-mail Huanghe at huanghe.yang@duke.edu with your CV and a brief description of your background, experience and skills.