Harward Lab
Our research aims to understand how ultrasound applied outside of the brain can modulate neuronal activity and potentially influence both pathology and physiology. By understanding the molecular and cellular mechanisms involved, we hope to translate these results into the development of novel uses of ultrasound to treat a wide variety of neurologic conditions in humans with exquisite precision but without the need for invasive surgery or device implantation. Diseases we are interested in include epilepsy, movement disorders, depression, anxiety, PTSD, addiction, obesity, and memory impairment.
Harward Research
The Harward Laboratory investigates the use of focused ultrasound (FUS) as a noninvasive tool for precision neuromodulation and neural circuit engineering. Our research seeks to understand how FUS influences the brain across multiple scales, from cellular signaling and synaptic plasticity to alterations in the extracellular matrix (ECM) that may facilitate adaptive circuit remodeling. We are particularly interested in the therapeutic potential of ultrasound neuromodulation for neurological and neuropsychiatric disorders, with ongoing efforts to define the mechanisms by which ultrasound can safely and selectively modulate neural activity. In parallel, we are developing sonogenetic approaches that combine focused ultrasound with genetically targeted actuators to achieve cell-type-specific neuromodulation, enabling precise interrogation and manipulation of neural circuits. Together, these studies aim to establish a foundation for next-generation, noninvasive therapies capable of restoring normal brain function through targeted modulation of neural networks.
Harward Lab Members
Coming soon.
Publications
Open Positions
We currently have an opening for a postdoctoral fellow.
Interested candidates should send their CV, a brief statement of research interests and goals, and the names and contact information of 3 references to Steve Harward at sch17@duke.edu