Velmeshev Lab
The goal of the Velmeshev lab is to understand normal human brain development and neurodevelopmental diseases at the single cell level.
We are particularly interested in gaining a holistic view of how genetic programs instruct neural progenitors give rise to the diverse cell types of the brain and guide formation of neuronal circuits, and how these processes are affected in brain disorders, such as autism.
The human brain contains billions of specialized neurons connected by trillions of synapses, as well as diverse types of glia. We approach studying this enormous complexity by combining single-cell genomics and spatial transcriptomic approaches with viral labelling of cell lineages and synapses. We apply these methods to human brain tissue samples, cerebral organoids and mouse models.
Selected Publications
Single-cell genomics identifies cell type–specific molecular changes in autism
Velmeshev D, Schirmer L, Jung D, Haeussler M, Perez Y, Mayer S, Bhaduri A, Goyal N, Rowitch DH, Kriegstein AR.
Science, 2019
Neuronal vulnerability and multilineage diversity in multiple sclerosis
Lucas Schirmer*, Dmitry Velmeshev*, ... Arnold R Kriegstein, David H Rowitch
* - co-first author
Nature, 2019
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
Jiasheng Zhang*, Dmitry Velmeshev*, Kei Hashimoto*, Yu-Hsin Huang*, ... Arnold R Kriegstein, Eric J Huang
* - co-first author
Nature, 2020
Dmitry Velmeshev, Marco Magistri, Emilia Maria Cristina Mazza, Patrick Lally, Nathalie Khoury, Evan Ross D’Elia, Silvio Bicciato, Mohammad Ali Faghihi
Molecular Neurobiology, 2020
Dmitry Velmeshev, Marco Magistri, Mohammad Ali Faghihi
Molecular Autism, 2013
Join Us
The Velmeshev Lab is currently hiring. The positions available are Postdoctoral Associate and Research Technician III. See below for links to apply.
External candidates:
POSTDOCTORAL ASSOCIATE - VELMESHEV LAB DEPARTMENT OF NEUROBIOLOGY (174590)
Internal candidates:
RESEARCH TECHNICIAN III - VELMESHEV LAB (176049)
External candidates:
RESEARCH TECHNICIAN III - VELMESHEV LAB (176049)