West Lab

355 Bryan Research

Anne E. West, MD, PhD, PI

Professor
Department of Neurobiology

Email: west@neuro.duke.edu

Phone: 919-681-1909

Location: 301D Bryan Research

Transcriptional Mechanisms of Activity-Dependent Synapse Development and Plasticity

In the West lab we study the molecular mechanisms and biological consequences of stimulus-regulated transcription in the CNS. The brain is a highly adaptable organ that is capable of converting environmental information into changes in neuronal function. Transcriptional regulators play an essential role in this process by transducing synaptic activity into changes in the regulation of neuronal gene expression programs that are required for the formation, maturation, and plasticity of synapses.

We use molecular genetic model systems, sophisticated behavioral analyses, biochemical and cell biological methods, and high-throughput sequencing techniques to elucidate the mechanisms by which transcriptional regulatory proteins promote neuronal adaptations to changes in the environment. In addition to enhancing understanding of normal brain development and plasticity, our studies are revealing new insights into how dysregulation of gene transcription contributes to cognitive impairment and mental illness.

 

Recent Posts

chan headshot
Event
Friday, March 11, 2022 - 09:30
Bryan Research 103
Urann Chan

PhD candidate Urann Chan, a member of the West Lab, will present his dissertation seminar Developmental Regulation of H3K27me3 Drives Exci

halvorsen headshot
Event
Wednesday, October 27, 2021 - 12:00
103 Bryan
Aaron Halvorsen

Second year Neurobiology graduate student Aaron Halvorsen (West Lab) will present “Rats and cocaine and synapses, oh my: Silent synapses during cocaine memory retrieval”, live in Bryan 103.  

neurons
News
Friday, October 15, 2021
By Alissa Kocer

Anne West, MD, PhD, professor of neurobiology, received a Faculty Scholar Award from the Ruth K. Broad Biomedical Research Foundation to study noncoding regulation of gene transcription in human neurons.

anne west headshot
News
Friday, August 13, 2021
By Alissa Kocer

A CRISPR-Cas9 variant with deactivated DNA-cutting function – known as “dCas9” - is a powerful tool to help researchers understand what genes do when their expression is dialed up or down, but it has some limitations. 

Pages