Yin Lab

3012 GSRBII

Henry Yin, Ph.D., PI

3012 Genome Sciences Research Building II
Box 91050, Duke University
Durham, NC 27708

Phone: 919 660 5781

Fax: 919 684 5778

Email: hy43@duke.edu

We study neural circuits underlying the learning and generation of actions. We use in vitro and in vivo electrophysiology, optogenetics, and quantitative analysis of behavior in rodents.

Current research in the lab encompasses three areas:

1. The analysis of cortico-basal ganglia networks using wired and wireless in vivo stimulation and recording in awake, behaving rodents combined with permanent and reversible lesions, optogenetics, and local pharmacological manipulations.

2. The analysis of voluntary behavior using operant procedures as well as video-based and automatic parsing of natural behaviors.

3. The cellular and molecular mechanisms of synaptic transmission and plasticity in the basal ganglia, a set of brain structures critical for the generation and selection of voluntary behaviors: e.g. the contributions of dopamine, adenosine, opioids, and endocanabinoids to glutamatergic and GABAergic transmission and plasticity.

Teaching

Brain and Behavior

Gateway course for the undergraduate neuroscience major

Fall every year